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喜讯:司法鉴定科学研究院使用IPHASE产品发表高质量文章(IF=2.5)

更新时间:2024-07-12      点击次数:144
  近日,司法鉴定科学研究院严慧课题组许琳灏老师,使用IPHASE品牌产品:人肝微粒体在《Journal of Analytical Toxicology》权·威期刊上发表文章《In vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines 》,影响因子2.5!
 
  本论文中,利用斑马鱼和人肝微粒体建立体外和体内模型,研究了三种苯换利定类物质的体外和体内代谢,采用液相色谱-高分辨率质谱法分析一相和二相代谢物,总共鉴定出49种代谢物。
 
  摘要
 
  Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-ketoarylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances have rapidly increasing illicit recreational use, the lack of detailed toxicity data are of particular concern. Therefore, analysis of their metabolites can help forensic personnel provide references and suggestions on whether a suspect has taken an illicit new psychoactive β-keto arylcyclohexylamine. The present study investigated the in vitro and in vivo metabolism and metabolites of three β-ketoarylcyclohexylamines: deschloro-N-ethyl-ketamine, fuoro-N-ethyl-ketamine and bromoketamine. In vitro and in vivo models were established using zebrafsh and human liver microsomes for analysis of Phase I and Phase II metabolites by liquid chromatography–high-resolution mass spectrometry. Altogether, 49 metabolites were identifed. The results were applied for the subject urine samples of known fuoro-N-ethyl ketamine consumer screen analysis in forensic cases. Hydroxy-deschloro-N-ethyl-ketamine, hydroxy-fuoro-N-ethyl-ketamine and hydroxy-bromoketamine were recommended as potential biomarkers for documenting intake in clinical and forensic cases.
 
完整版文献可在【IPHASE】公众号后台留言【获取文章】
 
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  凡使用本公司产品,在国内及国际刊物上发表论文(论文发表日起一年内),并注明产品属于IPHASE BIOSCIENCES Co.,Ltd. / 汇智和源生物技术(苏州)有限公司所有,即可申请奖励。根据发表刊物影响因子不同,给予不同金额奖品:
 
  非SCI论文及IF≤5分,500元礼品;
 
  5分
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  IF≥10分 2000元;
 
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